Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry

Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry
Liquid chromatography-mass spectrometry has been extensively applied as a strong software for offering in-depth characterization of nucleic acid therapeutic modalities, comparable to anti-sense oligonucleotides and small interfering RNAs (siRNAs). On this examine, we developed a generic hydrophilic interplay liquid chromatography (HILIC) hyphenated with tandem mass spectrometry methodology within the absence of ion-pairing reagents and demonstrated its functionality as a horny and strong different for oligonucleotide and siRNA evaluation.
HILIC separation of mixtures of unmodified and absolutely phosphorothioate-modified DNA oligonucleotides and their artificial 3′ exonuclease-digested metabolites had been additionally assessed. Excessive-resolution mass spectrometric (HRMS) evaluation was used to find out the deconvoluted plenty of oligonucleotide and siRNA requirements and their impurities.
To allow unbiased sequence characterization with tandem mass spectrometry (MS/MS), we additionally optimized higher-energy C-trap dissociation (HCD) on bettering the sequence protection of DNA and RNA oligonucleotides. Lastly, we evaluated on-column sensitivity for a phosphorothioate oligonucleotide by performing focused evaluation with both focused chosen ion monitoring (tSIM) or parallel response monitoring (PRM). Greater on-column sensitivity of 13 ng, equal to 2.Zero pmol, of a phosphorothioate oligonucleotide was achieved by tSIM evaluation as in comparison with PRM evaluation.

Hydrophilic nanofibers as a supersaturating supply system for carvedilol

Polymer nanofibers symbolize a promising supply system for poorly water-soluble medication; nevertheless, their supersaturating potential has not been explored but. Right here, carvedilol-loaded nanofibers primarily based on poly(ethyleneoxide) and on amphiphilic block copolymer poloxamer 407 had been produced by electrospinning.
These nanofibers offered excessive carvedilol loading and improved dissolution of carvedilol. Their dissolution resulted in a supersaturated system that was not steady, and thus to keep away from carvedilol precipitation, hydroxypropyl methylcelluloses or polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus) had been moreover integrated into the nanofibers. The morphology of the electrospun product was not affected by incorporation of carvedilol and the polymer precipitation inhibitors, as proven by scanning electron microscopy.
The hydroxypropyl methylcelluloses weren’t efficient polymer precipitation inhibitors for carvedilol. Incorporation of Soluplus considerably prolonged the period of carvedilol supersaturation (>24 h) in comparison with the dissolution of nanofibers with out Soluplus.
Furthermore, after 1 h of dissolution, incorporation of Soluplus into the nanofibers offered considerably increased carvedilol focus (94.4 ±2.5 μg/mL) in comparison with the nanofibers with out Soluplus (32.7 ±5.Eight μg/mL), the polymer movie (24.0 ±2.2 μg/mL), and the bodily combination (3.3 ±0.Four μg/mL). Thus, this examine exhibits the nice potential for hydrophilic nanofibers as a supply system for sustained carvedilol supersaturation.

Incorporation of simvastatin into lipid membranes: Why ship a statin in type of inclusion complicated with hydrophilic cyclodextrin

On this work, the consequences of simvastatin (SIM), (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and their complicated (SIM:HPβCD) on the construction and properties of lipid membranes had been investigated for the primary time by Langmuir approach mixed with PM-IRRAS spectroscopy. An improved understanding of the variations of the interactions between free SIM, and SIM within the type of an inclusion complicated with HPβCD with the lipid membrane will enhance the event of preparation strategies for in vivo purposes.
Monolayers of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), ldl cholesterol (Chol) and their combination DMPC:Chol (7:3) served as easy fashions of 1 leaflet of the cell membrane. The penetration of well-organized lipid layers by simvastatin result in their fluidization however the extent of this undesirable impact was smaller when the drug was delivered within the type of the SIM:HPβCD complicated.
Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry
Floor strain vs. time dependencies confirmed that the drug encapsulated with cyclodextrin dissociated from the complicated upon contact with the lipid layer and the weak interactions between the outside polar a part of the HPβCD and the polar headgroups of the lipid layer facilitated clean incorporation of the launched lipophilic drug into the membrane.
At an extended time-scale, the HPβCD ligand launched from the complicated eliminated some ldl cholesterol, however not DMPC, from the lipid layer, therefore, equally to the enzyme inhibiting motion of statins – it result in the lower of the quantity of ldl cholesterol within the membrane. Supply of simvastatin within the type of an inclusion complicated with HPβCD is proposed as an method bettering its bioavailability within the cholesterol-lowering therapies.

Software of cation-π interactions in enzyme-substrate binding: Design, synthesis, organic analysis, and molecular dynamics insights of novel hydrophilic substrates for NQO1

Cation-π interplay is a kind of noncovalent interplay fashioned between the π-electron system and the positively charged ion or moieties. On this examine, we designed a collection of novel NQO1 substrates by introducing aliphatic nitrogen-containing aspect chains to suit with the L-shaped pocket of NQO1 by the formation of cation-π interactions.
Molecular dynamics (MD) simulation indicated that the fundamental N atom within the aspect chain of NQO1 substrates, which is susceptible to be protonated beneath physiological circumstances, can type cation-π interactions with the Phe232 and Phe236 residues of the NQO1 enzyme.
Compound Four with a methylpiperazinyl substituent was recognized as probably the most environment friendly substrate for NQO1 with the discount charge and catalytic effectivity of 1263 ± 61 μmol NADPH/min/μmol NQO1 and a couple of.8 ± 0.3 × 106 M-1s-1, respectively. Notably, compound Four exhibited elevated water solubility (110 μg/mL) in comparison with that of β-lap (43 μg/mL), particularly beneath acidic situation (pH = 3, solubility > 1000 μg/mL). Compound 4 (IC50/A549 = 2.4 ± 0.6 μM) confirmed potent antitumor exercise in opposition to NQO1-rich most cancers cells by ROS technology by way of NQO1-mediated redox biking.

Fluorescent Carboxyl Superparamagnetic Particles

FCM-02552--2H 2mL
EUR 339.6
Description: Fluorescent Carboxyl Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Superparamagnetic Microparticles, 1-2µm

18879-5 5ml
EUR 390

BioMag® Superparamagnetic Iron Oxide, ~10µm

84200-10 10ml
EUR 676

Amino Silica Particles

ASIP-30-10 10 mL
EUR 372
Description: Amino Silica Particles are non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates.

Amino Magnetic Particles

AMS-40-10 10 mL
EUR 286.8
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMS-40-100 100 mL
EUR 1862.4
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMS-40-10H 10 mL
EUR 303.6
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-10-10 10 mL
EUR 230.4
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-10-100 100 mL
EUR 1424.4
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-150-5 5 mL
EUR 444
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-30-10 10 mL
EUR 230.4
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-40-10 10 mL
EUR 230.4
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-10-10 10 mL
EUR 254.4
Description: Amino Superparamagnetic Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules.

Amino Magnetic Particles

AM-10-100 100 mL
EUR 1618.8
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-15-10 10 mL
EUR 254.4
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-15-100 100 mL
EUR 1618.8
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-20-10 10 mL
EUR 261.6
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-20-100 100 mL
EUR 1668
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-30-10 10 mL
EUR 261.6
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-30-100 100 mL
EUR 1668
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-40-10 10 mL
EUR 261.6
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-40-100 100 mL
EUR 1668
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-60-10 10 mL
EUR 376.8
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-60-100 100 mL
EUR 2593.2
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-80-10 10 mL
EUR 444
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Polystyrene Particles

AP-025-10 10 mL
EUR 230.4
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-025-100 100 mL
EUR 1424.4
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-05-10 10 mL
EUR 230.4
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-05-100 100 mL
EUR 1424.4
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-08-10 10 mL
EUR 230.4
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-08-100 100 mL
EUR 1424.4
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-10-10 10 mL
EUR 249.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-10-100 100 mL
EUR 1570.8
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-100-10 10 mL
EUR 273.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-20-10 10 mL
EUR 261.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-20-100 100 mL
EUR 1668
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-25-10 10 mL
EUR 273.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-25-100 100 mL
EUR 1765.2
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-30-10 10 mL
EUR 273.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-30-100 100 mL
EUR 1765.2
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-35-10 10 mL
EUR 273.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-35-100 100 mL
EUR 1765.2
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-60-10 10 mL
EUR 327.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-60-100 100 mL
EUR 2203.2
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-100-10 10 mL
EUR 358.8
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-100-100 100 mL
EUR 2446.8
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-20-10 10 mL
EUR 339.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-30-10 10 mL
EUR 339.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-60-10 10 mL
EUR 339.6
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Fluorescent Particles

AFP-0252-2 2 mL
EUR 237.6
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0256-2 2 mL
EUR 237.6
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0552-2 2 mL
EUR 237.6
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0558-2 2 mL
EUR 237.6
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0852-2 2 mL
EUR 254.4
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0856-2 2 mL
EUR 254.4
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0858-2 2 mL
EUR 254.4
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0862-2 2 mL
EUR 254.4
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0865-2 2 mL
EUR 254.4
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-40052-5 5 mL
EUR 339.6
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino FerroMagnetic Particles

AFM-40-10 10 mL
EUR 254.4
Description: Amino FerroMagnetic Particlesare prepared using chromium dioxide coated onto uniform polystyrene particles. These particles retain magnetism once exposed to a magnetic field. Tested and valideted for the following research areas: mechanotransduction across the cell surface and through the cytoskeleton by binding ferromagnetic particles to cell surface receptors and applying mechanical stress directly to the receptor using a device to twist the magnetic particle on the cell surface.Key fearure is that they can be demagnetized and remagnetized repeatedly and reproducibly.

Amino PMMA Blue Particles

APBMA-30-5 5 mL
EUR 298.8
Description: Amino PMMA Blue ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Blue Particles

APBX-30-5 5 mL
EUR 298.8
Description: Amino Polystyrene Blue ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Fluorescent Amino Magnetic Particles

FAM-2052-2 2 mL
EUR 254.4
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Amino Magnetic Particles

FAM-2058-2 2 mL
EUR 254.4
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Amino Magnetic Particles

FAM-4056-2 2 mL
EUR 267.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Amino Particle Array Kit

APAK-3567-7K 7X1 mL
EUR 669.6
Description: Amino Particle Array KitGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

DiagNano Amine Silica Particles, 200 nm

DNG-F036 10 mL
EUR 721.2

DiagNano Amine Silica Particles, 300 nm

DNG-F037 10 mL
EUR 721.2

DiagNano Amine Silica Particles, 500 nm

DNG-F038 10 mL
EUR 721.2

Absolute Mag Amine Magnetic Particles, 100 nm

WHM-X014 1 mL
EUR 727.2

Absolute Mag Amine Magnetic Particles, 150 nm

WHM-X015 1 mL
EUR 727.2

Absolute Mag Amine Magnetic Particles, 200 nm

WHM-X016 1 mL
EUR 727.2

Absolute Mag Amine Magnetic Particles

WHM-Q001 10 mL
EUR 670.8

Absolute Mag Amine Magnetic Particles

WHM-Q003 10 mL
EUR 670.8

Absolute Mag Amine Magnetic Particles

WHM-Q004 10 mL
EUR 670.8

Absolute Mag Amine Magnetic Particles

WHM-Q017 10 mL
EUR 670.8

Absolute Mag Amine Magnetic Particles

WHM-Q019 10 mL
EUR 670.8

Absolute Mag Amine Magnetic Particles

WHM-Q020 10 mL
EUR 670.8

Absolute Mag Amine Magnetic Particles

WHM-Q021 10 mL
EUR 670.8

DiagNano Amine Silica Particles, 1 μm

DNG-F039 10 mL
EUR 739.2

DiagNano Amine Silica Particles, 1.5 μm

DNG-F040 10 mL
EUR 745.2

DiagNano Amine Silica Particles, 3 μm

DNG-F041 10 mL
EUR 745.2

DiagNano Amine Silica Particles, 4 μm

DNG-F042 10 mL
EUR 745.2

DiagNano Amine Silica Particles, 5 μm

DNG-F043 10 mL
EUR 745.2

DiagNano Amine Silica Particles, 10 μm

DNG-F044 10 mL
EUR 764.4

DiagNano Amine Silica Particles, 15 μm

DNG-F045 10 mL
EUR 764.4

DiagNano Amine Silica Particles, 20 μm

DNG-F046 10 mL
EUR 764.4

DiagPoly Amine Polystyrene Particles, 0.2 µm

DNM-F001 10 mL
EUR 696

DiagPoly Amine Polystyrene Particles, 0.3 µm

DNM-F002 10 mL
EUR 696

DiagPoly Amine Polystyrene Particles, 0.4 µm

DNM-F003 10 mL
EUR 696

DiagPoly Amine Polystyrene Particles, 0.5 µm

DNM-F004 10 mL
EUR 714

DiagPoly Amine Polystyrene Particles, 0.6 µm

DNM-F005 10 mL
EUR 714

DiagPoly Amine Polystyrene Particles, 0.7 µm

DNM-F006 10 mL
EUR 714

DiagPoly Amine Polystyrene Particles, 0.8 µm

DNM-F007 10 mL
EUR 714

DiagPoly Amine Polystyrene Particles, 0.9 µm

DNM-F008 10 mL
EUR 721.2

DiagPoly Amine Polystyrene Particles, 1.0 µm

DNM-F009 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 2.0 µm

DNM-F010 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 2.5 µm

DNM-F011 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 3.0 µm

DNM-F012 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 3.5 µm

DNM-F013 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 4.0 µm

DNM-F014 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 5.0 µm

DNM-F015 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 6.0 µm

DNM-F016 10 mL
EUR 987.6

DiagPoly Amine Polystyrene Particles, 7.0 µm

DNM-F017 10 mL
EUR 987.6

DiagPoly Amine Polystyrene Particles, 8.0 µm

DNM-F018 10 mL
EUR 788.4

DiagPoly Amine Polystyrene Particles, 10.0 µm

DNM-F019 10 mL
EUR 920.4

DiagPoly Amine Polystyrene Particles, 12.0 µm

DNM-F020 10 mL
EUR 920.4

Absolute Mag Amine Magnetic Particles, 50 nm

WHM-X012 1 mL
EUR 727.2

DiagNano Red Fluorescent, Amine Silica Particles, 200 nm

DNG-L049 10 mL
EUR 814.8

DiagNano Red Fluorescent, Amine Silica Particles, 300 nm

DNG-L052 10 mL
EUR 814.8

DiagNano Red Fluorescent, Amine Silica Particles, 500 nm

DNG-L057 10 mL
EUR 814.8

Absolute Mag Amine Magnetic Particles, 0.5-1.0 μm

WHM-Q065 10 mL
EUR 670.8

Absolute Mag Amine Magnetic Particles, 1.0-1.4 μm

WHM-S018 10 mL
EUR 724.8

Absolute Mag Amine Magnetic Particles, 1.5-1.9 μm

WHM-S019 10 mL
EUR 724.8

Absolute Mag Amine Magnetic Particles, 2.0-2.9 μm

WHM-S020 10 mL
EUR 745.2

Absolute Mag Amine Magnetic Particles, 3.0-3.9 μm

WHM-S021 10 mL
EUR 745.2

Absolute Mag Amine Magnetic Particles, 4.0-4.9 μm

WHM-S022 10 mL
EUR 745.2

Absolute Mag Amine Magnetic Particles, 6.0-6.9 μm

WHM-S023 10 mL
EUR 883.2

Absolute Mag Amine Magnetic Particles, 8.0-9.9 μm

WHM-S024 10 mL
EUR 945.6

DiagNano Blue Fluorescent, Amine Silica Particles, 200 nm

DNG-L050 10 mL
EUR 838.8

DiagNano Blue Fluorescent, Amine Silica Particles, 300 nm

DNG-L054 10 mL
EUR 838.8

DiagNano Blue Fluorescent, Amine Silica Particles, 500 nm

DNG-L056 10 mL
EUR 838.8

DiagNano Green Fluorescent, Amine Silica Particles, 200 nm

DNG-L051 10 mL
EUR 814.8

DiagNano Green Fluorescent, Amine Silica Particles, 300 nm

DNG-L053 10 mL
EUR 814.8

DiagNano Green Fluorescent, Amine Silica Particles, 500 nm

DNG-L055 10 mL
EUR 814.8

DiagNano Red Coloured, Amine Silica Particles, 3 μm

DNG-L131 10 mL
EUR 795.6

DiagNano Red Coloured, Amine Silica Particles, 5 μm

DNG-L134 10 mL
EUR 795.6

DiagNano Red Coloured, Amine Silica Particles, 10 μm

DNG-L136 10 mL
EUR 795.6

DiagNano Red Coloured, Amine Silica Particles, 15 μm

DNG-L137 10 mL
EUR 795.6

DiagNano Red Coloured, Amine Silica Particles, 20 μm

DNG-L140 10 mL
EUR 795.6

Absolute Mag Amine Magnetic Poly(lactic acid) Particles, 100 µm

WHM-G173 10 mL
EUR 692.4

DiagNano Blue Coloured, Amine Silica Particles, 3 μm

DNG-L132 10 mL
EUR 795.6

DiagNano Blue Coloured, Amine Silica Particles, 5 μm

DNG-L133 10 mL
EUR 795.6

DiagNano Blue Coloured, Amine Silica Particles, 10 μm

DNG-L135 10 mL
EUR 795.6

DiagNano Blue Coloured, Amine Silica Particles, 15 μm

DNG-L138 10 mL
EUR 795.6

DiagNano Blue Coloured, Amine Silica Particles, 20 μm

DNG-L139 10 mL
EUR 795.6

Absolute Mag Amine Dextran Magnetic Particles, 35 nm

WHM-P009 2 mL
EUR 1501.2

Absolute Mag Amine Magnetic Particles, Ferromagnetic

WHM-S008 10 mL
EUR 724.8

Absolute Mag Amine Magnetic Particles, Smooth Surface

WHM-S046 10 mL
EUR 727.2

Silica Particles

SIP-05-10 10 mL
EUR 218.4
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates.

Silica Particles

SIP-10-10 10 mL
EUR 225.6
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates.

Silica Particles

SIP-15-10 10 mL
EUR 237.6
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates.

Silica Particles

SIP-30-10 10 mL
EUR 237.6
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates.

Silica Particles

SIP-60-10 10 mL
EUR 249.6
Description: Silica Particlesare non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates.

DiagNano Red Fluorescent, Amine Silica Particles, 1 μm

DNG-L058 10 mL
EUR 820.8

DiagNano Red Fluorescent, Amine Silica Particles, 1.5 μm

DNG-L061 10 mL
EUR 814.8
These outcomes emphasised that the applying of cation-π interactions by introducing fundamental aliphatic amine moiety is useful for each the water solubility and the NQO1-substrate binding, resulting in promising NQO1-targeting antitumor candidates with improved druglike properties.

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