Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry

Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry
Liquid chromatography-mass spectrometry has been extensively applied as a strong software for offering in-depth characterization of nucleic acid therapeutic modalities, comparable to anti-sense oligonucleotides and small interfering RNAs (siRNAs). On this examine, we developed a generic hydrophilic interplay liquid chromatography (HILIC) hyphenated with tandem mass spectrometry methodology within the absence of ion-pairing reagents and demonstrated its functionality as a horny and strong different for oligonucleotide and siRNA evaluation.
HILIC separation of mixtures of unmodified and absolutely phosphorothioate-modified DNA oligonucleotides and their artificial 3′ exonuclease-digested metabolites had been additionally assessed. Excessive-resolution mass spectrometric (HRMS) evaluation was used to find out the deconvoluted plenty of oligonucleotide and siRNA requirements and their impurities.
To allow unbiased sequence characterization with tandem mass spectrometry (MS/MS), we additionally optimized higher-energy C-trap dissociation (HCD) on bettering the sequence protection of DNA and RNA oligonucleotides. Lastly, we evaluated on-column sensitivity for a phosphorothioate oligonucleotide by performing focused evaluation with both focused chosen ion monitoring (tSIM) or parallel response monitoring (PRM). Greater on-column sensitivity of 13 ng, equal to 2.Zero pmol, of a phosphorothioate oligonucleotide was achieved by tSIM evaluation as in comparison with PRM evaluation.

Hydrophilic nanofibers as a supersaturating supply system for carvedilol

Polymer nanofibers symbolize a promising supply system for poorly water-soluble medication; nevertheless, their supersaturating potential has not been explored but. Right here, carvedilol-loaded nanofibers primarily based on poly(ethyleneoxide) and on amphiphilic block copolymer poloxamer 407 had been produced by electrospinning.
These nanofibers offered excessive carvedilol loading and improved dissolution of carvedilol. Their dissolution resulted in a supersaturated system that was not steady, and thus to keep away from carvedilol precipitation, hydroxypropyl methylcelluloses or polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus) had been moreover integrated into the nanofibers. The morphology of the electrospun product was not affected by incorporation of carvedilol and the polymer precipitation inhibitors, as proven by scanning electron microscopy.
The hydroxypropyl methylcelluloses weren’t efficient polymer precipitation inhibitors for carvedilol. Incorporation of Soluplus considerably prolonged the period of carvedilol supersaturation (>24 h) in comparison with the dissolution of nanofibers with out Soluplus.
Furthermore, after 1 h of dissolution, incorporation of Soluplus into the nanofibers offered considerably increased carvedilol focus (94.4 ±2.5 μg/mL) in comparison with the nanofibers with out Soluplus (32.7 ±5.Eight μg/mL), the polymer movie (24.0 ±2.2 μg/mL), and the bodily combination (3.3 ±0.Four μg/mL). Thus, this examine exhibits the nice potential for hydrophilic nanofibers as a supply system for sustained carvedilol supersaturation.

Incorporation of simvastatin into lipid membranes: Why ship a statin in type of inclusion complicated with hydrophilic cyclodextrin

On this work, the consequences of simvastatin (SIM), (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and their complicated (SIM:HPβCD) on the construction and properties of lipid membranes had been investigated for the primary time by Langmuir approach mixed with PM-IRRAS spectroscopy. An improved understanding of the variations of the interactions between free SIM, and SIM within the type of an inclusion complicated with HPβCD with the lipid membrane will enhance the event of preparation strategies for in vivo purposes.
Monolayers of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), ldl cholesterol (Chol) and their combination DMPC:Chol (7:3) served as easy fashions of 1 leaflet of the cell membrane. The penetration of well-organized lipid layers by simvastatin result in their fluidization however the extent of this undesirable impact was smaller when the drug was delivered within the type of the SIM:HPβCD complicated.
Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry
Floor strain vs. time dependencies confirmed that the drug encapsulated with cyclodextrin dissociated from the complicated upon contact with the lipid layer and the weak interactions between the outside polar a part of the HPβCD and the polar headgroups of the lipid layer facilitated clean incorporation of the launched lipophilic drug into the membrane.
At an extended time-scale, the HPβCD ligand launched from the complicated eliminated some ldl cholesterol, however not DMPC, from the lipid layer, therefore, equally to the enzyme inhibiting motion of statins – it result in the lower of the quantity of ldl cholesterol within the membrane. Supply of simvastatin within the type of an inclusion complicated with HPβCD is proposed as an method bettering its bioavailability within the cholesterol-lowering therapies.

Software of cation-π interactions in enzyme-substrate binding: Design, synthesis, organic analysis, and molecular dynamics insights of novel hydrophilic substrates for NQO1

Cation-π interplay is a kind of noncovalent interplay fashioned between the π-electron system and the positively charged ion or moieties. On this examine, we designed a collection of novel NQO1 substrates by introducing aliphatic nitrogen-containing aspect chains to suit with the L-shaped pocket of NQO1 by the formation of cation-π interactions.
Molecular dynamics (MD) simulation indicated that the fundamental N atom within the aspect chain of NQO1 substrates, which is susceptible to be protonated beneath physiological circumstances, can type cation-π interactions with the Phe232 and Phe236 residues of the NQO1 enzyme.
Compound Four with a methylpiperazinyl substituent was recognized as probably the most environment friendly substrate for NQO1 with the discount charge and catalytic effectivity of 1263 ± 61 μmol NADPH/min/μmol NQO1 and a couple of.8 ± 0.3 × 106 M-1s-1, respectively. Notably, compound Four exhibited elevated water solubility (110 μg/mL) in comparison with that of β-lap (43 μg/mL), particularly beneath acidic situation (pH = 3, solubility > 1000 μg/mL). Compound 4 (IC50/A549 = 2.4 ± 0.6 μM) confirmed potent antitumor exercise in opposition to NQO1-rich most cancers cells by ROS technology by way of NQO1-mediated redox biking.

Aldehyde Superparamagnetic Particles

GLM-025-5H 5mL
EUR 233
Description: Amino Magnetic Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules.

Aldehyde Superparamagnetic Particles

GLM-05-5H 5mL
EUR 243
Description: Amino Polystyrene Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules.

Silica Superparamagnetic Particles

SIM-025-10H 10mL
EUR 208
Description: Silica Superparamagnetic Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules.

Silica Superparamagnetic Particles

SIM-05-10H 10mL
EUR 233
Description: Silica Superparamagnetic Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules.

Fluorescent Carboxyl Superparamagnetic Particles

FCM-02552--2H 2mL
EUR 283
Description: Fluorescent Carboxyl Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMS-40-10 10 mL
EUR 239
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMS-40-100 100 mL
EUR 1552
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMS-40-10H 10 mL
EUR 253
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-10-10 10 mL
EUR 192
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-10-100 100 mL
EUR 1187
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-150-5 5 mL
EUR 370
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-30-10 10 mL
EUR 192
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AMX-40-10 10 mL
EUR 192
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Polystyrene Particles

AP-025-10 10 mL
EUR 192
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-025-100 100 mL
EUR 1187
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-05-10 10 mL
EUR 192
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-05-100 100 mL
EUR 1187
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-08-10 10 mL
EUR 192
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-08-100 100 mL
EUR 1187
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-10-10 10 mL
EUR 208
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-10-100 100 mL
EUR 1309
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-100-10 10 mL
EUR 228
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-20-10 10 mL
EUR 218
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-20-100 100 mL
EUR 1390
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-25-10 10 mL
EUR 228
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-25-100 100 mL
EUR 1471
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-30-10 10 mL
EUR 228
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-30-100 100 mL
EUR 1471
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-35-10 10 mL
EUR 228
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-35-100 100 mL
EUR 1471
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-60-10 10 mL
EUR 273
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

AP-60-100 100 mL
EUR 1836
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-100-10 10 mL
EUR 299
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-100-100 100 mL
EUR 2039
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-20-10 10 mL
EUR 283
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-30-10 10 mL
EUR 283
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Particles

APX-60-10 10 mL
EUR 283
Description: Amino Polystyrene ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Silica Particles

ASIP-30-10 10 mL
EUR 310
Description: Amino Silica Particles are non-porous, spherical in shape, and are very uniform in size. These particles have a density of Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. .96 g/cm3 and can withstand temperatures of up to Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. 000°C. They have been used to adsorb DNA and RNA from cell lysates.

Amino FerroMagnetic Particles

AFM-40-10 10 mL
EUR 212
Description: Amino FerroMagnetic Particlesare prepared using chromium dioxide coated onto uniform polystyrene particles. These particles retain magnetism once exposed to a magnetic field. Tested and valideted for the following research areas: mechanotransduction across the cell surface and through the cytoskeleton by binding ferromagnetic particles to cell surface receptors and applying mechanical stress directly to the receptor using a device to twist the magnetic particle on the cell surface.Key fearure is that they can be demagnetized and remagnetized repeatedly and reproducibly.

Amino Fluorescent Particles

AFP-0252-2 2 mL
EUR 198
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0256-2 2 mL
EUR 198
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0552-2 2 mL
EUR 198
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0558-2 2 mL
EUR 198
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0852-2 2 mL
EUR 212
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0856-2 2 mL
EUR 212
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0858-2 2 mL
EUR 212
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0862-2 2 mL
EUR 212
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-0865-2 2 mL
EUR 212
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Fluorescent Particles

AFP-40052-5 5 mL
EUR 283
Description: Gentaur distributes carboxyl, amino, functionalized surface groups used for covalent coupling . If you need more technical information please contact our dedicated team via live chat, phone or email.

Amino Magnetic Particles

AM-10-10 10 mL
EUR 212
Description: Amino Superparamagnetic Particles are recomended for variety of applications such as cell separation, affinity purification, DNA probe assays, magnetic particle EIA, etc. The key features are does not contain any free iron oxide, thus reducing undesirable interference, you may obtain iable and functionally active cells using using magnetic labeling after coupling with cell surface molecules.

Amino Magnetic Particles

AM-10-100 100 mL
EUR 1349
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-15-10 10 mL
EUR 212
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-15-100 100 mL
EUR 1349
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-20-10 10 mL
EUR 218
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-20-100 100 mL
EUR 1390
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-30-10 10 mL
EUR 218
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-30-100 100 mL
EUR 1390
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-40-10 10 mL
EUR 218
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-40-100 100 mL
EUR 1390
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-60-10 10 mL
EUR 314
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-60-100 100 mL
EUR 2161
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino Magnetic Particles

AM-80-10 10 mL
EUR 370
Description: Amino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Amino PMMA Blue Particles

APBMA-30-5 5 mL
EUR 249
Description: Amino PMMA Blue ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Amino Polystyrene Blue Particles

APBX-30-5 5 mL
EUR 249
Description: Amino Polystyrene Blue ParticlesGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Fluorescent Amino Magnetic Particles

FAM-2052-2 2 mL
EUR 212
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Amino Magnetic Particles

FAM-2058-2 2 mL
EUR 212
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Amino Magnetic Particles

FAM-4056-2 2 mL
EUR 223
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Amino Flunitrazepam

80-1101 500 ul
EUR 414
Description: 7-Amino Flunitrazepam Conjugate for use in immunoassays

Amino Tadalafil

C3266-10 10 mg
EUR 181
Description: Amino tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5).PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5?-GMP.

Amino Tadalafil

C3266-100 100 mg
EUR 676
Description: Amino tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5).PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5?-GMP.

Amino Tadalafil

C3266-5 5 mg
EUR 119
Description: Amino tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5).PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5?-GMP.

Amino Tadalafil

C3266-50 50 mg
EUR 432
Description: Amino tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5).PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5?-GMP.

Fluorescent Particles

FP-00552-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-00556-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-00558-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-00562-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-00570-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0245-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0252-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0256-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0257-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0262-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0270-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0545-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0552-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0556-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0557-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0558-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0562-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0570-2 2 mL
EUR 182
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0842-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0845-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0852-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0856-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0857-2 2 mL
EUR 202
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0858-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0862-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0868-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0870-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-0878-2 2 mL
EUR 188
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10040-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10045-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10052-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10056-10 10 mL
EUR 740
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10056-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10056-2A 2X1 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10062-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10066-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10067-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10070-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10074-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-10078-2 2 mL
EUR 259
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-15052-2 2 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-15056-2 2 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-15062-2 2 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-15066-2 2 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-15070-2 2 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-1552-2 2 mL
EUR 202
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-20052-5 5 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-20056-5 5 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2042-2 2 mL
EUR 218
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2045-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2054-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2056-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2057-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2058-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2060-2 2 mL
EUR 218
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2062-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2065-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2068-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-2070-2 2 mL
EUR 192
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-30052-5 5 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-30056-5 5 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-30062-5 5 mL
EUR 283
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3042-2 2 mL
EUR 218
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3052-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3055-2 2 mL
EUR 218
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3056-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3057-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3058-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3065-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3066-2 2 mL
EUR 218
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3068-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3069-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3070-2 2 mL
EUR 198
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Fluorescent Particles

FP-3074-2 2 mL
EUR 202
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
These outcomes emphasised that the applying of cation-π interactions by introducing fundamental aliphatic amine moiety is useful for each the water solubility and the NQO1-substrate binding, resulting in promising NQO1-targeting antitumor candidates with improved druglike properties.

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